Research Interests

The Dalton lab is interested in the basic biology of pluripotent cells, including mouse and human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). These studies will help understand more about early stages of embryonic development and are directed towards a better understanding of cell cycle control, the pluripotent state and cell fate decisions made by pluripotent cells. A second major effort in the lab is dedicated towards developing cell therapies for cardiovascular disease, diabetes and neurological disorders. The Dalton lab has been particularly successful in developing methods for the generation of cardiac and neural progenitor cells which are being evaluated in animal models.

News from the Dalton Lab

  • The 2012 Southeast Stem Cell Consortium annual meeting will be held in Tallahassee, at Florida State University. This will be followed by the 2013 meeting at the University of Alabama, Birmingham.
  • David Reynolds has taken a position at the Walter and Eliza Hall Institute of Medical Research (WEHI), Melbourne, Australia. Congratulations Dave!
  • Congratulations to Keri Smith and Amar Singh for their paper being accepted for publication in Cell Stem Cell.
  • Matt Bechard has accepted a post-doctoral position at Vanderbilt University to work with Dr. Chris Wright on pancreatic development- good luck Matt!
  • Keri Smith has recently started a post-doc with Dr. Terry Magnusson at the University of North Carolina.- congratulations Keri!
  • Well done to James Chappell who recently published an article in BMC Biology.
  • Congratulations to Amar Singh and David Reynolds for being selected to present talks at the 3rd Southeast Stem Cell Consortium Workshop, Vanderbilt University, Tennessee.
  • The 3rd annual Southeast Stem Cell Consortium Workshop is due to be held on July 22nd-23rd. This years meeting is being convened by Dr. Trish Labosky (Vanderbilt University.). For further information go to www.sestemcells.uga.edu.
  • The 2nd UGA PO1 PPG retreat was held at the Ritz-Carlton, Reynolds Plantation, Lake Oconee (August 2-3, 2011). Guest speakers; Tim Townes (UAB, Birmingham) and Angie Rizzino (University of Nebraska Medical Center). Participants came from from University of Georgia, Florida State University, University of Alabama (Birmingham), Georgia Health Sciences University, Vanderbilt University, University of Florida.

Positions in the Dalton Lab

There are post-doctoral positions currently open to work in several areas. Please contact Stephen Dalton for details.

Highlighted Publications

  • Dalton, S. (2009). “Exposing hidden dimensions of embryonic stem cell cycle control.” Cell Stem Cell 4: 9-10.
  • Bechard, S. and Dalton, S. (2009). “PI3K/AKT1 and GSK3b control embryonic stem cell fate decisions by a novel mechanism converging on c-myc”. Mol Cell Biol. 29: 2092-2104.
  • Singh, A. and Dalton, S. (2009). “The cell cycle and Myc intersect with mechanisms for pluripotency and reprogramming.” Cell Stem Cell 5, 141-149.
  • Smith, K., Singh, A. and Dalton, S. (2010) “Myc sustains pluripotency by repressing primitive endoderm specification.” Cell Stem Cell 7, 343-354.
  • Smith, K.N., Lim, J.M., Wells, L. and Dalton, S. (2011). “Myc orchestrates a regulatory network for the establishment and maintenance of pluripotency.” Cell Cycle 10, 592-597.
  • Menendez, L., Yatskievych, T.A., Antin, P.A. and Dalton, S. “Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells.” Proc. Natl. Acad. Sci. USA (in press).